In Vivo RNA LANCEr

MaxSuppressor™ In Vivo RNA-LANCEr uses a novel non-toxic blend of fat-soluble naturally-occurring hydrophobic molecules to efficiently deliver siRNA and miRNA into mouse organs.  The advanced formulation enables users to to deliver RNAi agents, in vivo, for target validation and drug target identification purposes. After formulating RNAi agents with MaxSuppressor™ In Vivo RNA-LANCEr, the RNA becomes stable in serum, preventing the need for stability modifications which reduces the synthesis cost.

Dried siRNA/RNA-LANCEr cake is stable for extended periods of time at -20°C allowing preparation of the small RNAs to be done days before the injection is performed. Injection of this agent via the tail vein has been shown to give the most efficient gene reduction in the liver, lung and kidney.  However, the delivery route can be focused so that more efficient uptake and reduction may be obtained in your desired destination. The siRNA may be directly injected into a subcutaneous tumor or into a specific organ using surgical procedures.

BIOO related product, MaxSuppressor™Cell Culture RNA-LANCEr (cat. 3302).