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3514-02

CD1c (Human Thymus Leukemia)Catalog #: 3514-02

CD1c (Human Thymus Leukemia Antigen) Monoclonal Antibody

CD1c is one of five human CD1 isoforms, a family of b2-microglobulin-associated transmembrane proteins that bind and present lipid antigens to T cells. M241 is useful for identification and elimination of some leukemias.

Antigen: CD1c (Human Thymus Leukemia antigen)

Clone number: M241

Immunogen: MOLT 4 cell line

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: IP, RIA

Isotype: IgG1

References: Knowles et al. 1982. Eur. J. Immunol. 12:676-681.
Small TN. 1989. Hum. Immunol. 25:181-193.

Notes: ---

Quantity: 100µg

M241

100 µg

266.00 EUR

3514-03

CD3 (Purkinje cell antigen, T3)Catalog #: 3514-03

CD3 (Purkinje Cell Antigen, T3) Monoclonal Antibody

The CD3 complex composed of five CD3 polypeptide chains, associates with the T cell antigen receptor (TCR) and is found on all mature human T lymphocytes. UCH-T1 can be used for the detection of T cell populations in peripheral blood and lymph nodes and the categorization of T versus B cell lymphomas and leukemias. Indication of prognosis in leukemia and lymphoma. UCH-T1 has mitogenic activity.

Antigen: CD3 (Purkinje cell antigen, T3)

Clone number: UCH-T1

Immunogen: Human infant thymocytes and Sezary cells

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: RIA, IHC (F), IF

Isotype: IgG1

References: Beverley P & Callard R. 1981. Euro. J. Immunol. 11(4):329-334.
Garson JA et al. 1982. Nature. 298:375-377.
Dornan S et al. 2002. J. Biol. Chem. 277(3):1912-8.
Notes: Use: Enrichment of T cell populations by cell sorting or panning. There is mitogenic activity with this monoclonal antibody.

Quantity: 100µg

UCH-T1

100 µg

266.00 EUR

3514-01

CD4 V1 DomainCatalog #: 3514-01

CD4 V1 Domain Monoclonal Antibody

CD4 is a T cell co-receptor that recognizes, together with the T cell receptor, MHC class II molecules. CD4 cell counts are used as indicator of AIDS progression. In addition to virus binding, CD4 may have an active role in membrane fusion.

Antigen: CD4 V1

Clone number: QS4120

Immunogen: CD4+ transfectant followed by CEM cells

Species reactivity: ---

Host species: Mouse: Balb/c

Applications: ELISA, FACS

Isotype: IgG1

References: Healey D et al. 1990. J. Exp. Med. 172(4):1233-1242.
Dornan S et al. 2002. J. Biol. Chem. 277(3):1912-8.
Notes: Inhibits HIV sycytium function on cocultivation assay.

Quantity: 100 µg

QS4120

100 µg

266.00 EUR

3514-04

CD5 (Leu-1)/UCH-T2Catalog #: 3514-04

CD5 (Leu-1) Monoclonal Antibody

CD5 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukemia cells that binds CD72. Absence of the CD5 marker on childhood ALL cells is associated with a more favorable prognosis. UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorization of T cell lymphomas and B cell chronic lymphocytic leukemia.

Antigen: CD5 (Leu-1)

Clone number: UCH-T2

Immunogen: Thymocytes followed by Sezary T cells

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: IHC (F), IF

Isotype: IgG1

References: Beverley P & Callard R. 1982. Protides Biol. Fluids. 29:653-658.

Notes: Use: Immunofluorescence and immunostaining frozen, enrichment of T cell populations by cell sorting or panning.

Quantity: 100µg

UCH-T2

100 µg

266.00 EUR

3514-05

CD5 (Leu-1)/H65Catalog #: 3514-05

CD5 (Leu-1) Monoclonal Antibody

CD5 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukemia cells that binds CD72. Absence of the CD5 marker on childhood ALL cells is associated with a more favorable prognosis. H65 has reactivity towards 85-95% peripheral blood T lymphocytes and 95% thymocytes.

Antigen: CD5 (Leu-1)

Clone number: H65

Immunogen: HSB-2 cells

Species Reactivity: ---

Host Species: Mouse: Balb/c

Applications: RIA, IP, IHC

Isotype: IgG1

References: 1st International Workshop on Human Leukocyte Differentiation Antigens (CodeT34) Paris. 1982.

Notes: ---

Quantity: 100µg

H65

100 µg

266.00 EUR

3514-06

CD8 (Leu-2)/14Catalog #: 3514-06

CD8 (Leu-2) Monoclonal Antibody

CD8 is a T cell co-receptor that recognizes, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. 14 can be used for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorization of T cell acute lymphoblastic leukemia and lymphoblastic lymphoma in conjunction with other antigens and determination of T4/T8 ratios in immune deficiencies, rheumatoid arthritis, multiple sclerosis, etc.

Antigen: CD8 (Leu-2)

Clone number: 14

Immunogen: Fibronectin purified monocytes

Species Reactivity: ---

Host Species: ---

Applications: IHC (F)

Isotype: IgG1

References: Hogg N et al. 1999. J. Clin. Invest. 103(1):97-106.

Notes: Use: T-cell enrichment by cell sorting or panning.

Quantity: 100µg

14

100 µg

266.00 EUR

3514-07

CD8 (Leu-2)/UCH-T4Catalog #: 3514-07

CD8 (Leu-2) Monoclonal Antibody

CD8 is a T cell co-receptor that recognizes, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. UCH-T4 can be used for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorization of T cell acute lymphoblastic leukemia and lymphoblastic lymphoma in conjunction with other antigens and determination of T4/T8 ratios in immune deficiencies, rheumatoid arthritis, multiple sclerosis, etc.

Antigen: CD8 (Leu-2)

Clone number: UCH-T4

Immunogen: Thymocytes followed by Sezary T cells

Species Reactivity: ---

Host Species: Mouse: Balb/c

Applications: IHC (F), FACS

Isotype: IgG2a

References: Beverley P. 1982. Proc. Royal Soc. Edin. 81B:221-232.
Kee WJ et al. 2000. J. Cell Biochem. 78(1):97-111.

Notes: Antigen is a 32 kDa cell surface protein.

Quantity: 100µg

UCH-T4

100 µg

266.00 EUR

3514-08

CD8 (Leu-2a) Catalog #: 3514-08

CD8 (Leu-2a) Monoclonal Antibody

CD8 is a T cell co-receptor that recognizes, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. M236 is useful for the identification of cytotoxic/suppressor cell subpopulation in peripheral blood, elimination of cytotoxic/suppressor cell subpopulation from peripheral blood and bone marrow, elimination of some T cell leukemias and blocking of cytotoxic activity.

Antigen: CD8 (Leu-2a)

Clone number: M236

Immunogen: MOLT 4 cell line

Species Reactivity: ---

Host Species: Mouse: Balb/c

Applications: RIA, IP

Isotype: IgG1

References: 1st International Workshop on Human Leukocyte Differentiation Antigens (code T67), Paris, and November 1982.

Notes: The antigen is a 32kDa MW protein.

Quantity: 100µg

M236

100 µg

266.00 EUR

3514-09

CD14Catalog #: 3514-09

CD14 Monoclonal Antibody

CD14 is found in human monocytes and vascular endothelium in some tissues. CD14 binds the endotoxin lipopolysaccharide. UCH-M1 can be used to investigate specific in vitro antibody responses to influenza virus by human lymphocytes.

Antigen: CD14

Clone number: UCH-M1

Immunogen: Thymocytes and peripheral blood leucocytes (PBL)

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: FACS, ICH (A), IF

Isotype: IgG2a

References: Hogg N et al. 1984. Immunology. 53:753-767.

Notes: Activates complement. 52 kDa MW

Quantity: 100µg

UCH-M1

100 µg

266.00 EUR

3514-10

CD35 (CR1)Catalog #: 3514-10

CD35 Monoclonal Antibody

CD35 is found on many leucocytes and binds C3b and C4b. E11 detects the C3b/C4b receptor present on most leukemic monoblasts and also normal granulocytes, but which is not expressed on leukemic myoblasts. Used to define B cell lymphomas.

Antigen: CD35 (Human complement receptor 1; CR1)

Clone number: E11

Immunogen: Acute monocytic leukemia cells and normal blood monocytes

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: IHC (A), IHC (F), IP

Isotype: IgG1

References: Hogg N et al. 1984. Eur. J. Immunol. 14:236-243.
Leukocyte Typing III. Edited by AJ McMichael et al. 1987

Notes: ---

Quantity: 100µg

E11

100 µg

266.00 EUR

3514-11

CD36 (Thrombospondin receptor)Catalog #: 3514-11

CD36 (Thrombospondin Receptor) Monoclonal Antibody

CD36 is a class B scavenger receptor found in vascular endothelium, platelets and monocytes. CD36 binds thrombospondin and oxidized low density lipoprotein (LDL).

Antigen: CD36 (Thrombospondin receptor)

Clone number: SMF

Immunogen: Tonsil cells and PBM

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: IHC (A), IHC (F), N, FACS, IF

Isotype: IgM

References: Hogg N et al. 1984. Immunology. 53:753-767.
Leukocyte Typing IV. 1989.

Notes: ---

Quantity: 100µg

SMΦ

100 µg

266.00 EUR

3514-12

CD45 (LCA)/C11Catalog #: 3514-12

CD45 (Leukocyte Common Antigen; LCA) Monoclonal Antibody

CD45 is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple CD45 isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumors. C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumors.

Antigen: CD45 (Leukocyte Common Antigen; LCA)

Clone number: C11

Immunogen: Human lymphocytes

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: IHC (F), IP

Isotype: IgG2a

References: ---

Notes: 180-220 kDa isoforms of CD45

Quantity: 100µg

C11

100 µg

266.00 EUR

3514-13

CD45 (LCA)/Hle-1 (2D1) Catalog #: 3514-13

CD45 (Leukocyte Common Antigen; LCA) Monoclonal Antibody

CD45 is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple CD45 isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumors. Hle-1 can be used in a panel of several monoclonal antibodies to characterize tumors.

Antigen: CD45 (Leukocyte Common Antigen; LCA)

Clone number: Hle-1 (2D1)

Immunogen: Ficoll-Triosil-separated human peripheral blood mononuclear cells

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: IHC (F), FACS, IF

Isotype: IgG1

References: Bradstock KF et al. 1980. J. Nat. Cancer Inst. 65:33-42.

Tchilian EZ et al. 2001. J. Immunol. 166(2):1308-13.

Notes: 180-220 kDa MW

Quantity: 100µg

Hle-1 (2D1)

100 µg

266.00 EUR

3514-14

CD45RCatalog #: 3514-14

CD45R Monoclonal Antibody

CD45 is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple CD45 isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumors. 351C5 can be used in typing of leukemias and lymphomas and in research on functional subsets of B and T cells. 351C5 can be used in typing of leukemias and lymphomas and in research on functional subsets of B and T cells.

Antigen: CD45R

Clone number: 351C5

Immunogen: Raji cells

Species Reactivity: Human

Host Species: ---

Applications: IP, FACS, IHC (F)

Isotype: IgM

References: Murray LJ et al. 1985. Clin. Exp. Immunol. 59:315-326.

Notes: ---

Quantity: 100µg

351C5

100 µg

266.00 EUR

3514-15

CD45ROCatalog #: 3514-15

CD45 RO Monoclonal Antibody

CD45 is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple CD45 isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumors. UCH-L1 may identify abnormalities of functional T-cell subsets in immune disorders and can be used in tumor diagnosis by FACS or immunohistology. Very useful in studies of human T cell function and ontogeny.

Antigen: CD45 RO

Clone number: UCH-L1

Immunogen: Cultured T cells from an IL-2-dependent T-cell line (CA1) prepared from human peripheral blood activated with influenza virus.

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: FACS, WB, IP, IHC (F), IHC (P), IHC (Fm)

Isotype: IgG2a

References: Smith SH et al. 1986. Immunol. 58:63-70.
Dornan S et al. 2002. J. Biol. Chem. 277(3):1912-8.

Notes: ---

Quantity: 100µg

UCH-L1

100 µg

266.00 EUR

3514-16

CD55 (DAF)Catalog #: 3514-16

CD55 (Decay Accelerating Factor: DAF) Monoclonal Antibody

CD55 is a distinctive marker of synovium. CD55 protects tissues from attack by autologous complement by interfering with the assembly of C3 convertase.

Antigen: CD55 (Decay Accelerating Factor: DAF)

Clone number: 67

Immunogen: Fibronectin purified monocytes

Species Reactivity: ---

Host Species: ---

Applications: IHC (A), IHC (F)

Isotype: IgG1

References: Palmer DG et al. 1985. Clin. Exp. Immunol. 59:529-538.
Leitinger B et al. 2002. J. Cell. Sci. 115:963-72.

Notes: ---

Quantity: 100µg

67

100 µg

266.00 EUR

3514-17

CD64Catalog #: 3514-17

CD64 (Fc?-Receptor I; Fc?-RI) Monoclonal Antibody

CD64 is an IgG receptor expressed by monocytes and myeloid cell lines. 10.1 blocks Ig binding to FcR1 receptor, and may block ADCC. It is an indicator of inflammation. Increased expression of FcR1 on monocytes after interferon treatment.

Antigen: CD64 (Fc?-Receptor I; Fc?-RI)

Clone number: 10.1

Immunogen: Rheumatoid synovial fluid cells and fibronectin purified human monocytes

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: IHC, FACS, IP

Isotype: IgG1

References: Dougherty et al. 1987. Eur. J. Immunol. 17:1453-1459.
Jayaram Y et al. 1989. Clin. Exp. Immunol. 75:414.

Notes: 71 kDa MW

Positive control: myeloid cell lines U937 and HL60.

Quantity: 100µg

10.1

100 µg

266.00 EUR

3514-18

CDw90 (Thy-1)Catalog #: 3514-18

CDw90 (Thy-1) Monoclonal Antibody

Thy-1 is a GPI-anchored glycoprotein expressed in the brain, thymocytes and T lymphocytes. aThy-1A1 has use in bone marrow purging.

Antigen: CDw90 (Thy-1)

Clone number: aThy-1A1

Immunogen: Purified Thy-1

Species Reactivity: ---

Host Species: ---

Applications: IP, IHC, FACS

Isotype: IgG2a

References: Cotmore SF et al. 1981. Eur. J. Immunol. 11:597-603.

Notes: ---

Quantity: 100µg

aThy-1A1

100 µg

266.00 EUR

3514-19

Fibrin alpha chainCatalog #: 3514-19

Fibrin a Chain Monoclonal Antibody

A monocyte and neuronal antigen present predominantly on a protein of 45kDa MW. UC45 is specific for monocytic leukemias. The relevant antigens are not expressed in all cases with monocytic differentiation.

Antigen: Fibrin a chain

Clone number: UC45

Immunogen: Human acute monoblastic leukemia cells

Species Reactivity: Human

Host Species: Mouse: Balb/c

Applications: IF, RIA, IHC

Isotype: IgM

References: Hogg N et al. 1981. Cell. 24:875-884.
Hogg N et al. 1984. Eur.J. Immunol. 63(3):566-573.

Notes: Also reacts with fibrinogen

Quantity: 100µg

UC45

100 µg

266.00 EUR

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