Cytochrome P450
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Référence |
Anticorps |
Clone |
Qté |
Prix
Unitaire
Euros HT |
| 3512-01 |
CYP 1A2Catalog #: 3512-01
CYP 1A2 Monoclonal Antibody
CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolizing enzymes in humans.
Antigen: CYP 1A2
Clone number: D15 (16VII F10F12)
Immunogen: Rat liver P4501A2
Species reactivity: Human, Rat, Mouse
Host species: Mouse
Applications: ELISA, WB
Isotype: IgG1
References:---
Notes: D15 does not cross react with rat CYP 2A1, 2B1, 2B2, 2C6, 2C7, 2C11, 4A1, 4A2 and 4A3. D15 does cross react with CYP 1A1 & CYP 1A2 with high affinity in all species tested.
Quantity: 100 µg |
D15 (16VII F10F12) |
100 µg |
266.00 EUR |
| 3512-02 |
CYP 2B1 & 2B2 - b/e3 Catalog #: 3512-02
CYP 2B1 and 2B2 Antibody
The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P-450s.
Antigen: Rat Cytochrome P450 2B1 and 2B2. Cross reacts with rat 2B10
Clone number: b/e3 (9.14)
Immunogen: Rat liver cytochrome P4502B1 and 2B2
Species reactivity: Rat and Mouse
Host species: Mouse
Applications: ELISA, WB
Isotype: IgG1
References:---
Notes: b/e3 does not react with Rat CYP 1A1, 1A2, 2A1, 2C6, 2C7, 2C11, 4A2 and 4A3. b/e3 inhibits PROD activity in liver microsomes of PB-treated rats. b/e3 inhibits ECOD activity in liver microsomes of PB-treated but not 3MC-treated rats. The CYP2B1 antibody recognises the major barbiturate-inducible P450s in mouse and rat. The absence of reactivity with human CYP2B6 indicates in will not work in this species.
Quantity: 100 µg |
b/e3 (9.14) |
100 µg |
266.00 EUR |
| 3512-03 |
CYP 2B1 & 2B2 - b/e4Catalog #: 3512-03
CYP 2B1 and 2B2 Antibody
The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P-450s.
Antigen: Cytochrome P450 2B1 and 2B2
Clone number: b/e4 (9.20)
Immunogen: Rat liver cytochromes P450 2B1 and 2B2
Species reactivity: Rat
Host species: Mouse
Applications: ELISA, WB
Isotype: IgG1
References:---
Notes: b/e4 does not react with CYP 1A1, 1A2, 2C6, 2C2, 2C7, 2C11, 4A2, 4A3. Cross reacts with untreated mouse, beagle and baboon.
Quantity: 100 µg |
b/e4 (9.20) |
100 µg |
266.00 EUR |
| 3512-04 |
CYP 2C2, 2B1, 2B1 - h7Catalog #: 3512-04
CYP 2C2, 2B1, 2B1 Antibody
The Cytochrome P450 2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substance.
Antigen: Cytochrome P450 2C2, 2B1, 2B1 (rat)
Clone number: h7 (11II D12A2)
Immunogen: Rat liver cytochrome P450 2C2
Species reactivity: Rat (not tested in other species)
Host species: Mouse
Applications: ELISA, WB
Isotype: IgG1
References:---
Notes: ELISA. Strong cross-reactivity with rat CYP 2C2, 2B1, 2B2, weakly reactin with CYP 2C6, 4A1 and 4A3. In western blots H7 does not react with rat CYP 1A1, 1A2, 2C6, 2C7, 4A2 & 4A3.
Quantity: 100 µg |
h7 (11II D12A2) |
100 µg |
266.00 EUR |
| 3512-05 |
CYP 2C6 - K1Catalog #: 3512-05
CYP 2C6 Antibody
The Cytochrome P450 2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances.
Antigen: Cytochrome P450 2C6 (Rat)
Clone number: K1 (213xB12C6)
Immunogen: Rat liver cytochrom P450 2C6
Species reactivity: Rat Human and Mouse
Host species: Mouse
Applications: ELISA, WB
Isotype: IgG1
References:---
Notes: The K1 antibody cross reacts with rat CYP 2C6 & human CYP 2C9, as well as other CYP 2C human proteins. It is also reactin with a phenobarbital-inducible CYP 2C protein in mice. K1 does not react with human, rat and mouse CYP 2C8.
Quantity: 100 µg |
K1 (213xB12C6) |
100 µg |
266.00 EUR |
| 3512-06 |
CYP 3A4, 3A1, 3A11 - P6Catalog #: 3512-06
CYP 3A4 (Human), 3A1 (Rat), 3A11 (Mouse) Antibody
In animals, P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1, 2, 3, and 4. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.
Antigen: Cytochrome P450 3A1 (Rat)
Clone number: P6
Immunogen: Rat liver cytochrome P450 3A1
Species reactivity: Rat Human and Mouse
Host species: Mouse
Applications: ELISA, WB
Isotype: IgG1
References:---
Notes: P6 is highly specific for members of the CYP 3A gene family. It cross reacts with family members across species recognising CY 3A4 in human, CYP 3A in rat and probably CYP 3A11 (based on inducibility) in mice. Cross reactivity with other CYP 3A proteins cannot be precluded.
Quantity: 100 µg |
P6 |
100 µg |
266.00 EUR |
| 3512-07 |
CYP 4A1, 4A2, 4A3 - Clo 4 Catalog #: 3512-07
CYP 4A1, 4A2, 4A3 Antibody
In animals, P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The hepatic CYP4A enzymes are important fatty acid and prostaglandin omega-hydroxylases that are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators. In humans, 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels.
Antigen: Cytochrome P450 41, 4A2 and 4A3
Clone number: clo4 (17 VI H12A11)
Immunogen: Rat liver cytochrome P450 4A2 and 4A3
Species reactivity: Rat (not tested in any other species)
Host species: Mouse
Applications: ELISA, WB
Isotype: IgG2a
References:---
Notes: clo4 does not react with CYP 1A1, 1A2, 2A1, 2B1, 2B2, 2C6 and 2C7. Cross reacts with untreated mouse, cat, beagle, guinea-pig, rabbit, marmoset, baboon and human.
Quantity: 100 µg |
clo4 (17 VI H12A11) |
100 µg |
266.00 EUR |
| 3512-08 |
CYP 4A1 - Clo1Catalog #: 3512-08
CYP 4A1 Antibody
In animals, P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The hepatic CYP4A enzymes are important fatty acid and prostaglandin omega-hydroxylases that are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators. In humans, 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels.
Antigen: Cytochrome P450 4A1
Clone number: clo1 (h1)
Immunogen: Rat liver cytochrome P450 2C11 and 4A1
Species reactivity: Rat
Host species: Mouse
Applications: ELISA, WB
Isotype: IgG2b
References: Monoclonal Antibodies Diagnostics for Individual Members of the Cytochromes P450IV Gene Family", Abstract 205 at the VIIIth Inter. Symp. on Microsomes and Drug Oxidations, Stockholm, Sweden, June 25-26, 1990.
"Monoclonal Antibodies Diagnostics for Individual Members of the Cytochromes P450IV Gene Family", Abstract 1.36 at the 12th Eur. Work. on Drug Metabolism, Basel, Switzerland, Sept. 16-21, 1990.
Notes: clo1 does not react with rat 1A1, 1A2, 2A1, 2B1, 2B2, 2C6, 2C7, 4A2 and 4A3. Cross reacts with untreated mouse, guinea pig, beagle, macacca fascicularis, baboon and human.
Quantity: 100 µg |
clo1 (h1) |
100 µg |
266.00 EUR |
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