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Anticorps
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Anticorps >

Protéines d'adhésion cellulaire

Pour plus de renseignement, cliquez sur les descriptions:

Référence	Anticorps	Clone	Qté	Prix Unitaire Euros HT
3510-07	Anticorps anti-CD15 (Lewis X), clone 28 Catalog #: 3510-07 CD15 (Lewis X) Antibody CD15 is a branched pentasaccharide found on neutrophils, eosinophils and monocytes. CD15 is distributed abnormally in myeloid leukemias. CD15 is commonly used in the diagnosis of Hodgkin’s disease. It can also be used for analysis of myeloid leukemias and studies of myeloid differentiation Antigen: CD15 Clone number: 28 Immunogen: Monocytes, separated from other peripheral blood leucocytes (PBL) on fibronectin plates. Species reactivity: --- Host species: Mouse: Balb/c Applications: IP, FACS, IHC (A/F) Isotype: IgM Reference: Hogg N et al. 1984. Immunology. 53:753-767. Linch D & Slusarenko M. 1984. Blood. 63(3):566-573. Notes: Does not activate complement. Quantity: 100 μg	28	100 µg	266.00 EUR
3510-08	Anticorps anti-CD15 (Lewis X), clone 29 Catalog #: 3510-08 CD15 (Lewis X) Antibody CD15 is a branched pentasaccharide found on neutrophils, eosinophils and monocytes. CD15 is distributed abnormally in myeloid leukemias. Clone 29 is useful for leukemia typing and purification of stem cells. Antigen: CD15 Clone number: 29 Immunogen: Fibronectin purified monocytes Species reactivity: --- Host species: --- Applications: FACS Isotype: IgM Reference: Bernstein I & Self S. Report of the myeloid section of the Second International Workshop on Leucocyte Typing II, Human leucocyte Differentiation Antigens. Published by Springer-Verlag, New York. 1986. Notes: --- Quantity: 100 μg	29	100 µg	266.00 EUR
3510-09	Anticorps anti-CD15 (Lewis X), clone TG-1Catalog #: 3510-09 CD15 (Lewis X) Antibody CD15 is a branched pentasaccharide found on neutrophils, eosinophils and monocytes. CD15 is distributed abnormally in myeloid leukemias. TG-1 is useful for differentiation of human leukocytes. Antigen: CD15 Clone number: TG-1 Immunogen: Thymocyte glycoprotein fraction adsorbed to Con A and eluted with 0.1M glucose. Species reactivity: --- Host species: Mouse: CBA Applications: IHC(A), IF, FACS Isotype: --- Reference: Beverley P et al. 1980. Nature. 287:332-333. Hogg N et al. 1984. Immunology. 53:753-767. Linch DC et al. 1984. Blood. 63:566-573. Notes: Cytotoxic with rabbit complement. Quantity: 100 μg	TG-1	100 µg	266.00 EUR
3510-10	Anticorps anti-CD44 (Homing Cell Adesion Molecule, HCAM)Catalog #: 3510-10 CD44 (Homing Cell Adesion Molecule, HCAM) Antibody CD44 is a broadly distributed receptor that binds hyaluronan. CD44 splice variants are associated with metastasis. Antigen: CD44 Clone number: P2A1 Immunogen: Ocular melanoma cell line (V+B2). Species reactivity: Human Host species: Mouse Applications: IHC(P), IP, FACS Isotype: --- Reference: Nath D et al. 1999. Immunol. 98(2):213-219 Notes: Cytotoxic with rabbit complement. Quantity: 100 μg	P2A1	100 µg	266.00 EUR
3510-25	Anticorps anti- L1 Cell Adhesion Molecule (L1CAM; CD171)Catalog #: 3510-25 L1 Cell Adhesion Molecule (L1CAM; CD171) Antibody L1 cell adhesion molecule (L1CAM) is a cell-surface glycoprotein and member of the neural adhesion molecule family of the immunoglobulin superfamily. L1CAM is implicated in the development of the nervous system and its expression is restricted to tissues arising from the neuroectoderm. L1CAM is present on tumors of neuroectodermal and glial origin (e.g. neuroblastoma and schwannomas). UJ127.11 may be useful in the diagnosis of embryonic tumors (e.g. neuroblastoma). Antigen: L1 cell adhesion molecule (L1CAM; CD171) Clone number: UJ127.11 Immunogen: Homogenous suspension of 16 week human foetal brain Species reactivity: Human Host species: Mouse: Female Balb/c Applications: WB, IP Isotype: IgG1 Reference: Kemshead JT et al. 1983. Int. J. Cancer 31:187-195 Patel K et al. 1990. Biochem. Soc. Transactions. 18:274 Notes: --- Quantity: 100 μg	UJ127.11	100 µg	266.00 EUR
3510-26	Anticorps anti-L1 Cell Adhesion Molecule (L1CAM; CD171)Catalog #: 3510-26 L1 Cell Adhesion Molecule (L1CAM; CD171) Antibody L1 cell adhesion molecule (L1CAM) is a cell-surface glycoprotein and member of the neural adhesion molecule family of the immunoglobulin superfamily. L1CAM is implicated in the development of the nervous system and its expression is restricted to tissues arising from the neuroectoderm. L1CAM is present on tumors of neuroectodermal and glial origin (e.g. neuroblastoma and schwannomas). UJ181.4 can be used in diagnosis of primitive neuroectodermal tumors. Binds to tumors of neural and glial origin and does not bind to paediatric or adult brain. Used for bone marrow purging and intrathecal targeting. Antigen: L1 cell adhesion molecule (L1CAM; CD171) Clone number: UJ181/4 Immunogen: 16 week human foetal brain Species reactivity: Human Host species: Mouse: Balb/c Applications: IP, WB Isotype: IgG1 Reference: Kemshead JT et al. 1983. Int. J. Cancer 31:187-195. Bourne S et al. 1989. Hybridoma. 8:415-426. Notes: 220/240 kDa MW Quantity: 100 μg	UJ181.4	100 µg	266.00 EUR
3510-27	Anticorps anti- CD146 (Mel-CAM; A32 antigen; MUC 18; S-endo) Antibody Catalog #: 3510-27 CD146 (Mel-CAM; A32 antigen; MUC 18; S-endo) Antibody CD146 has been identified as a cell adhesion molecule and is useful in differential diagnosis of certain lesions including melanomas and various types of gestational trophoblastic lesions. Antigen: MUC 18 (CD146) Clone number: OJ79c MUC18 Immunogen: Recombinant MUC18(D1-D5)Fc Protein Species reactivity: --- Host species: Mouse Applications: IHC(F), FACS Isotype: IgG1 Reference: Kuzu I et al. 1993. Lab. Invest. 69(3):322-328. Notes: Positive control - reactive tonsil negative for paraffin and WB. Quantity: 100 μg	18	100 µg	266.00 EUR

Intégrines:

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Référence	Description	Clone	Qté	Prix Unitaire Euros HT
3510-11	Anticorps anti-Integrin alpha2 (CD49b)_HAS-3 Catalog #: 3510-11 Integrin a2 (CD49b) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2 associates with integrin ß1 (CD29) to form the heterodimer integrin a2ß1, which is one of the most abundant keratinocyte integrins, is found distributed in the basal layer of epidermis and binds collagen. HAS-3 co-precipitates integrin a2ß1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen. Antigen: Integrin a2 (CD49b) Clone number: HAS-3 Immunogen: Whole human keratinocytes Species reactivity: Human Host species: Mouse Applications: IHC(F), IHC(Fm), IP, FACS Isotype: IgG2a Reference: Tenchini ML et al. 1993. Cell. Adhes. and Comm. 1:55-66 Alford D et al. 1998. J. Cell Sci. 111:521-32 Notes: --- Quantity: 100 µg	HAS-3	100 µg	266.00 EUR
3510-12	Anticorps anti-Integrin alpha2 (CD49b)_HAS-4 Catalog #: 3510-12 Integrin a2 (CD49b) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2 associates with integrin ß1 (CD29) to form the heterodimer integrin a2ß1, which is one of the most abundant keratinocyte integrins, is found distributed in the basal layer of epidermis and binds collagen. HAS-4 co-precipitates integrin a2ß1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen. Antigen: Integrin a2 (CD49b) Clone number: HAS-4 Immunogen: --- Species reactivity: Human Host species: Mouse Applications: IHC(formaldehyde), IP, FACS Isotype: IgG2a Reference: Tenchini ML et al. 1993. Cell. Adhes. and Comm. 1:55-66 Alford D et al. 1998. J. Cell Sci. 111:521-32 Notes: --- Quantity: 100 µg	HAS-4	100 µg	266.00 EUR
3510-13	Anticorps anti-Integrin alpha2b (CD41)_M148 Catalog #: 3510-13 Integrin a2b (CD41; GPllb) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 2b (CD41) and integrin ß3 (CD61) associate to form the heterodimer integrin a2bß3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. M148 prevents aggregation of platelets. Used for imaging and therapy of thrombi. M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and certain other solid tumors. No binding is observed to marrow constituents other than platelets and megakaryocytes. Antigen: Integrin a2b (CD41; GPllb) Clone number: M148 Immunogen: Homogenized human medulloblastoma tissue Species reactivity: Human Host species: Mouse: Balb/c. Applications: IP Isotype: IgG1 Reference: Jones D et al. 1984. Brit. J. Haem. 57:621-631 Notes: --- Quantity: 100 µg	M148	100 µg	266.00 EUR
3510-14	Anticorps anti-Integrin alpha2bß3(CD41/CD61) Catalog #: 3510-14 Integrin a2bß3 (CD41/CD61; GPllb/GPllla) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2b (CD41) and integrin ß3 (CD61) associate to form the heterodimer integrin a2bb3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. P256 has potential use for imaging of thrombi. P256 induces aggregation of normal platelets in plasma. Antigen: Integrin a2bß3 (CD41/CD61; GPllb/GPllla) Clone number: P256 Immunogen: Peripheral blood mononuclear cells Species reactivity: --- Host species: Mouse: Balb/c. Applications: IF, IP, WB Isotype: IgG1 Reference: Bai Y et al. 1983. Eur. J. Immunol. 13:521-527 Bachelot C et al. 1990. Eur. J. Biochem. 190:177-183 Notes: 135 kDa component of the glycoprotein IIa/IIIb complex on platelet and megakaryocytes cell membranes. Quantity: 100 µg	P256	100 µg	266.00 EUR
3510-15	Anticorps anti-Integrin alpha3 (CD49c)_IA3 Catalog #: 3510-15 Integrin a3 (CD49c) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3ß1, which is one of the most abundant keratinocyte integrins and binds laminin 5. IA3 is useful for studies on inhibition of cell-cell adhesion and cell-substrate adhesion. Antigen: Integrin a3 (CD49c) Clone number: IA3 Immunogen: Transfected human breast epithelial cell line MTSV1-7, hygromycin resistant. Species reactivity: --- Host species: Mouse: Balb/c. Applications: IHC(F) Isotype: IgG1 Reference: Berdichevsky F et al. 1994. J. Cell. Sci. 107:3557-68 Notes: --- Quantity: 100 µg	IA3	100 µg	266.00 EUR
3510-16	Anticorps anti-Integrin alpha6 (CD49f)_MP4F10 Catalog #: 3510-16 Integrin a6 (CD49f) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a6 is found on epithelial and endothelial basement membranes and colorectal carcinoma. Integrin a6 associates with integrin ß4 to form integrin a6ß4, which is one of the most abundant keratinocyte integrins and binds laminin. MP 4F10 can be used in clinical studies for tumor grading - stains moderately and well-differentiated colorectal adenocarcinoma. Antigen: Integrin a6 (CD49f) Clone number: MP 4F10 Immunogen: SW1222 human colorectal cell line. Species reactivity: Human Host species: Mouse: Balb/c. Applications: IP, IHC(F), FACS Isotype: IgG2b Reference: Anbazhagan R et al. 1995. J. Pathol. 176:227-232 Levy L et al. 2000. Mol. Biol. Cell. 11(2):453-66 Notes: No reaction on fixed formalin tissue Quantity: 100 µg	MP4F10	100 µg	266.00 EUR
3510-17	Anticorps anti-Integrin alphaM (CD11b)_ICRF44 Catalog #: 3510-17 Integrin aM (CD11b; Mac-1 a subunit; C3bi receptor) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin aM is found in neutrophils, monocytes and NK cells. Patients lacking integrin aM molecules have immune deficiency symptoms and commonly subject to bacterial and fungal infections. ICRF 44 blocks some functions of Mac-1. Antigen: Integrin aM (CD11b; Mac-1a subunit) Clone number: ICRF 44 Immunogen: Rheumatoid synovial cells and human monocytes. Species reactivity: Human, primate Host species: Mouse: Balb/c. Applications: IP, IHC(F), FACS Isotype: IgG1 Reference: Malhotra.V et al. 1986. Eur. J. Immunology. 16:1117-1123. Leucocyte Typing III. Edited by McMichael AJ et al. 1987. Notes: Recognizes the 160 kDa alpha subunit CD11b (of CD11b/CD18; alphaM beta2). Positive control: monocytes or neutrophils Quantity: 100 µg	ICRF44	100 µg	266.00 EUR
3510-18	Anticorps anti-Integrin alphaV (CD51)_13C2 Catalog #: 3510-18 Integrin aV (CD51) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin aV associates with integrin ß3 to form the osteoclast functional antigen (vitronectin receptor). Integrin aV is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin aV increases with melanoma progression. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment. Antigen: Integrin aV (CD51) Clone number: 13C2 Immunogen: A cell suspension containing osteoclasts from osteoclastomas Species reactivity: Human Host species: Mouse: Female Balb/c. Applications: IP, IHC(F), IHC(A), FACS Isotype: IgG1 Reference: Horton MA et al. 1985. Cancer Res. 45:5663-5669 Levy L et al. 2000. Mol. Biol. Cell. 11(2):453-66 (flow cytometry) Notes: --- Quantity: 100 µg	13C2	100 µg	266.00 EUR
3510-19	Anticorps anti-Integrin alphaV (CD51)_P2W7 Catalog #: 3510-19 Integrin aV (CD51) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin aV associates with integrin ß3 to form the osteoclast functional antigen (vitronectin receptor). Integrin aV is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin aV increases with melanoma progression. Antigen: Integrin aV (CD51) Clone number: P2W7 Immunogen: Ocular melanoma cell line (V+B2) a clone expressing high levels of alpha-v,beta-1 Species reactivity: Human Host species: --- Applications: IP, IF, WB, FACS Isotype: IgG1 Reference: Von Schlippe M et al. 2000. J. Cell Sci. 113:425-37 Notes: Positive control lysate: A375M melanoma cell line. Human alpha v is about 150-160kDa under non-reducing conditions. Under reducing conditions it is cleaved into 2 bands of about 125-130kDa +20-25kDa Quantity: 100 µg	P2W7	100 µg	266.00 EUR
3510-20	Anticorps anti-Integrin alphaVß3 (CD51/CD61) Catalog #: 3510-20 Integrin aVß3 (CD51/CD61; Vitronectin Receptor; Osteoclast Functional Antigen) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin aVß3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin aVß3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment. Antigen: Integrin aVß-3 (CD51/61; Osteoclast Functional Antigen) Clone number: 23C6 Immunogen: A cell suspension containing osteoclasts from osteoclastomas. Species reactivity: Human Host species: Mouse: Female Balb/c Applications: IHC(F/A), N, IP, FACS Isotype: IgG1 Reference: Horton MA et al. 1985. Cancer Res. 45:5663-5669. Marshall JF et al. 1995. J. Cell. Sci. 108:1227-38 Notes: Positive control: Tonsil. 125/124 kDa (reduced), 150kDa (non-reduced) Quantity: 100 µg	23C6	100 µg	266.00 EUR
3510-21	Anticorps anti-Integrin alphaX (CD11c)_3.9 Catalog #: 3510-21 Integrin aX (CD11c; gp150/95 a subunit) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin aX is found on hairy cell leukemias and malignant histiocytes and on tissue macrophages, monocytes, activated neutrophils and some T-cell clones. Antigen: Integrin aX (CD11c; gp150/95 a subunit) Clone number: 3.9 Immunogen: Rheumatoid synovial fluid cells and fibronectin purified human monocytes Species reactivity: --- Host species: Mouse: Balb/c Applications: IHC(F), IP, FACS Isotype: IgG1 Reference: Hogg N et al. 1986. Eur. J. Immunol. 16:240 -248. Leucocyte Typing III. Edited by McMichael AJ et al. 1997. Notes: Recognises the 150Kd alpha subunit CD11c (of CD11c/CD18 or p150,95) Positive control: monocytes or neutrophils. Quantity: 100 µg	3.9	100 µg	266.00 EUR
3510-22	Anticorps anti-Integrin ß1 (CD29)_4B7 Catalog #: 3510-22 Integrin ß1 (CD29) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Loss of integrin ß1 is associated with the development of some epithelial tumors. Antigen: Integrin ß1 (CD29) Clone number: 4B7 Immunogen: Ocular melanoma cell line V+B2 Species reactivity: Human Host species: Mouse: Balb/c Applications: IHC(P), IP, FACS, IF Isotype: IgG1 Reference: Marshall JF et al. 1998. Br. J. Cancer. 77(4):522-529 Notes: --- Quantity: 100 µg	4B7	100 µg	266.00 EUR
3510-23	Anticorps anti-Integrin ß3 (CD61)_F11 Catalog #: 3510-23 Integrin ß3 (CD61; GPllla) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin ß3 is expressed in osteoclasts, megacaryocytes and platelets. The F11 epitope is different to the MHF4 epitope. Antigen: Integrin ß3 (CD61) Clone number: F11 Immunogen: A bone cell suspension containing osteoclasts, osteoblasts and bone marrow cells obtained from the long bones of newborn Sprague Dawley rats. Species reactivity: Rat, weakly reactive with human Host species: Mouse: Balb/c Applications: IHC(F/Fm), IP, FACS, N Isotype: IgG1 Reference: Helfrich MH et al. 1992. J. Bone Miner. Res. 7(3):335-343. Helfrich MH et al. 1992. J. Bone Miner. Res. 7(3):345-351. Thompson RD et al. 2000. J. Immunol. 165(1):426-34. Shankar G et al. 1993. J Cell Sci. 105; 61-68. Notes: The antibody may be used to identify ostoclasts in tissue sections and bone cell suspensions. Quantity: 100 µg	F11	100 µg	266.00 EUR
3510-24	Anticorps anti-Integrin ß3 (CD61)_MHF4 Catalog #: 3510-24 Integrin ß3 (CD61; GPllla) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin ß3 is expressed in osteoclasts, megacaryocytes and platelets. MHF4 may be used to identify osteoclasts in tissue sections and bone cell suspensions. The MHF4 epitope is different to the F11 epitope. Antigen: Integrin ß3 chain (CD61) Clone number: MHF4 Immunogen: A bone cell suspension containing osteoclasts, osteoblasts and bone marrow cells obtained from the long bones of newborn Sprague Dawley rats. Species reactivity: Rat, Human Host species: Mouse: Balb/c Applications: IHC(F/A), IP, FACS Isotype: IgG1 Reference: Helfrich MH et al. 1992. J. Bone Miner. Res. 7(3):345-351. Notes: A heterodimeric molecule with a characteristic shift in apparent molecular mass on reduction (137/78 kDa nonreduced; 118/100 kDa reduced). Quantity: 100 µg	MHF4	100 µg	266.00 EUR
3510-02	Anticorps anti-Integrin alphaL Catalog #: 3510-02 Integrin aL (CD11;LFA-1 a subunit) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin aL is expressed on human leucocytes, with increased expression on memory T cells. 38 blocks CD11a functions (e.g. LFA-1/ICAM interactions). Antigen: Integrin aL (CD11; LFA-1 a subunit) Clone number: 38 Immunogen: Fibronectin purified monocytes Species reactivity: Human Host species: Mouse: Balb/c Applications: IP, N Isotype: IgG2a Reference: Hogg N et al. 1986. Eur. J. Immunol. 16:240-248. McDowall A et al. 2003. J. Clin. Invest. 111(1):51-60. Notes: --- Quantity: 100 µg	38	100 µg	266.00 EUR
3510-03	Anticorps anti-Integrin aL, aM, aX/ß2 Catalog #: 3510-03 Integrin aL, aM, aX/ß2 (CD11/ CD18) Antibody Integrins are heterodimeric cell surface receptors composed of a and ß subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. CD18 associates with CD11a (integrin aL) to form leukocyte function-associated antigen-1 (LFA-1), CD11b (integrin aM) to form Mac-1 and CD11c (integrin aX) to form gp150/95. CD11/CD18 integrins bind various ICAMs. 24 may be used as a reporter of the activation state of CD11/CD18 receptors, which are activated following exposure to Mg2+ or Mn2+. Antigen: Integrin aL, aM, aX/ß2 (CD11/ CD18) Clone number: 24 Immunogen: Fibronectin purified human monocytes Species reactivity: Human Host species: Mouse: Balb/c Applications: IP, FACS, RIA, FITC Isotype: IgG1 Reference: Hogg N and Selvendran Y. 1985. Cell. Immunol. 92:247-253. McDowall A et al. 2003. J. Clin. Invest. 111(1):51-60. Notes: Positive control: tonsil. CD18: 95 kDa, CD11: 180kDa Quantity: 100 µg	24	100 µg	266.00 EUR

ICAM:

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Référence	Description	Clone	Qté	Prix Unitaire Euros HT
3510-04	ICAM-1 (CD54)Catalog #: 3510-04 ICAM-1 (CD54) Antibody ICAMs are members of the immunoglobulin superfamily that is characterized by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). 15.2 blocks CD54 function. Antigen: ICAM-1 (CD54) Clone number: 15.2 Immunogen: Rheumatoid synovial cells and human monocytes Species reactivity: Human Host species: Mouse: Balb/c Applications: IP, FACS, IHC Isotype: IgG1 Reference: Dransfield I et al. 1992. J. Cell. Biol. 116:1527 1535. Stanley P et al. 2000. Biochem J. 351:79-86. Notes: Positive control: tonsil. CD18: 95 kDa, CD11: 180kDa Quantity: 100 µg	15.2	100 µg	266.00 EUR
3510-05	ICAM-3 (DC50) Catalog #: 3510-05 ICAM-3 (CD50) Antibody ICAMs are members of the immunoglobulin superfamily that is characterized by the presence of immunoglobulin-like domains. ICAM-3 is the major ligand for LFA-1 (CD11a/CD18) in the resting state. ICAM-3 may play a key role in initiating immune responses. ICAM 3.1 and ICAM 3.2 can be used to examine LFA-1/ICAM-3 adhesion. Antigen: ICAM-3 (CD50) Clone number: ICAM 3.1 Immunogen: ICAM-3Fc chimeric fusion protein Species reactivity: --- Host species: Mouse Applications: WB, IP, ELISA, RIA, IHC (F), FACS Isotype: IgG1 Reference: Holness CL et al. 1995. J. Biol. Chem. 270(2): 877-884. Bossy D et al. 1995. Eur. J. Immunol. 25(2):459-465. Notes: Western gives a 130KD band. Quantity: 100 µg	ICAM 3.1	100 µg	266.00 EUR

NCAM:

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Référence	Description	Clone	Qté	Prix Unitaire Euros HT
3510-28	NCAM (CD56)_UJ13A Catalog #: 3510-06 Neural Cell Adhesion Molecule (NCAM; CD56) Monoclonal Antibody Neural cell adhesion molecule (NCAM) is a cell-surface glycoprotein and member of the neural adhesion molecule family of the immunoglobulin superfamily. NCAM is implicated in the development of the nervous system. UJ13A may be useful as a diagnostic reagent in the characterization of neuro-ectodermally derived tumors and in the identification of metastatic spread to the bone marrow. UJ13A has been used in radioimmunoscintigraphy of neuroblastoma and brain tumors and in targeted radiotherapy. Antigen: Neural Cell Adhesion Molecule (NCAM; CD56) Clone number: UJ13A Immunogen: 16 week human fetal brain Species Reactivity: Human Host Species: Mouse: Balb/c Applications: WB, IF Isotype: IgG1 References: Allan et al. 1999. Int. J Cancer 31:591-598. Patel K et al. 1989. Br. J. Cancer 44:1062-1068. Notes: Western blot of 2 year pediatric brain revealed bands of 180, 140kDa in addition to a very weak band of 120 kDa with UJ13A Mab. Quantity: 100µg	UJ13A	100 µg	266.00 EUR
3510-06	NCAM (CD56)_ERIC-1 Catalog #: 3510-28 Neural Cell Adhesion Molecule (NCAM; CD56) Antibody Neural cell adhesion molecule (NCAM) is a cell-surface glycoprotein and member of the neural adhesion molecule family of the immunoglobulin superfamily. NCAM is implicated in the development of the nervous system. Antigen: Neural Cell Adhesion Molecule (NCAM; CD56) Clone number: ERIC-1 Immunogen: Retinoblastoma tissue membrane fraction. Species reactivity: Human Host species: Mouse: Balb/c Applications: IHC(F/A), IP, WB, ELISA, RIA Isotype: IgG1 Reference: Bourne SP et al. 1991. J. Neurooncol. 10:111-119. Phimister E et al. 1991. J. Clin. Pathol. 44:580-585. Notes: In the mouse brain, 3 main isoforms have been described of 180,140 and 120 kDa MW. A Western blot of 2 year old pediatric brain revealed bands of 180,140 and 120 kDa (weakly) with ERIC-1. Positive control: neuroblastome. Quantity: 100 µg	ERIC-1	100 µg	266.00 EUR

Siglecs:

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Référence	Description	Clone	Qté	Prix Unitaire Euros HT
3510-01	CD33 (Siglec-3)Catalog #: 3510-01 CD33 (Siglec-3) Monoclonal Antibody The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. CD33 is found on granulocyte and macrophage precursors in the bone marrow, but not on pluripotent stem cells. CD33 is also expressed on, and a useful marker for, peripheral monocytes. CD33 is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias. Antigen: CD33 (Siglec-3) Clone number: CD33 3D6 Immunogene: CD33-Fc recombinant protein Species reactivity: --- Host species: Mouse Applications: ELISA Isotype: IgG1 Reference: Freeman SD et al. 1995. Blood. 85(8):2005-12. Taylor VC et al. 1999. J. Biol. Chem. 274(17):11505-11512. Notes: Positive contol: CD33 transfected COS cells. Quantity: 100 µg	CD33 3D6	100 µg	266.00 EUR
3510-29	Sialoadhesin (Siglec-1)_HSn7D2 Catalog #: 3510-29 Sialoadhesin (Siglec-1) Antibody The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumors. Antigen: Sialoadhesin domains 1-4 (Siglec0-1) Clone number: HSn 7D2 Immunogen: Fc fusion protein containing N-terminal 4 domains of human sialoadhesin. Species reactivity: Human Host species: Mouse: Balb/c Applications: IHC(P/A/F), ELISA, RIA, FACS Isotype: IgG1 Reference: Hartnell A et al. 2001. Blood. 97(1):288-96. Steiniger B et al. 1997. Immunology. 92:307-316. Notes: --- Quantity: 100 µg	HSn 7D2	100 µg	266.00 EUR

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